{"id":8058,"date":"2019-05-15T10:49:52","date_gmt":"2019-05-15T08:49:52","guid":{"rendered":"http:\/\/zavnews.net\/?p=8058"},"modified":"2019-05-15T10:49:55","modified_gmt":"2019-05-15T08:49:55","slug":"hocemo-li-uskoro-reci-zbogom-injekcijama","status":"publish","type":"post","link":"https:\/\/zavnews.net\/index.php\/2019\/05\/15\/hocemo-li-uskoro-reci-zbogom-injekcijama\/","title":{"rendered":"Ho\u0107emo li uskoro re\u0107i zbogom injekcijama"},"content":{"rendered":"
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Postoje lijekovi koje nije mogu\u0107e popiti, jer ako ih se ne uzima putem injekcije, nego kroz usta \u2013 oni naprosto ne mogu djelovati. \u0160kolski primjer takvog lijeka je inzulin.<\/strong><\/p>\n\n\n\n

To je zato \u0161to je on po sastavu biomakromolekula, protein. Kad ih se unese u probavni sustav, proteini se potom razgra\u0111uju na inaktivne komponente koje nemaju nikakve ljekovite u\u010dinke. Upravo zato takvi lijekovi moraju biti ubrizgani direktno u krvnu \u017eilu.<\/p>\n\n\n\n

Mikrokapsule umjesto igala<\/h4>\n\n\n\n

Zato su sada na Harvardu i MIT-u osmislili nevjerovatan koncept injekcije koja ne boli. Lijek je naime, smje\u0161ten u mikropilulu veli\u010dine zrna gra\u0161ka. Ona se u \u017eelucu samostalno postavi u polo\u017eaj za primjenu lijeka, a zatim se automatski aktivira oprugica i utiskuje lijek u \u017eelu\u010danu stijenku.<\/p>\n\n\n\n

\u017delu\u010dani mi\u0161i\u0107 oblo\u017een sluznicom (\u017eelu\u010dana stijenka) nije opskrbljen \u017eiv\u010danim vlaknima za bol. Zato kada nas boli trbuh, ne boli mi\u0161i\u0107ni dio \u017eeluca, nego njegova vanjska vezivna ovojnica oboga\u0107ena \u017eivcima.<\/p>\n\n\n\n

Zato je dakle, ubod mikroinjekcije bezbolan. Takvom bezbolnom injekcijom se mo\u017ee isporu\u010diti ljekovita tvar koja ina\u010de ne bi \u201epre\u017eivjela\u201c prolazak kroz kiseli okoli\u0161 \u017eeluca i probavne sokove u crijevima.<\/strong><\/p>\n\n\n\n

U \u010dlanku objavljenom<\/a>\u00a0u nau\u010dnom \u010dasopisu\u00a0Science<\/em>, nau\u010dnici su objavili detalje prototipa \u201einjekcijske pilule\u201c.<\/strong> Dobili su pozitivne rezultate testova provedenih na svinjskim \u017eelucima u kojima su tim pilulama primjenjivali inzulin.<\/p>\n\n\n\n

Potencijalni problemi u primjeni<\/h4>\n\n\n\n

Iako su istra\u017eivanja jo\u0161 uvijek u povojima, dosada\u0161nji rezultati ukazuju na to da bi takva injekcija u piluli mogla biti primjenjiva i kod ljudi.<\/p>\n\n\n\n

U testovima na svinjama je injekcijska pilula uspje\u0161no ubrizgavala inzulin u \u017eelu\u010danu stijenku, \u010dak i kad su nau\u010dnici naginjali i rotirali \u017eivotinje.<\/p>\n\n\n\n

Razina \u0161e\u0107era u krvi svinja je poslije svake primjene kapsule bila smanjena, \u010dime se dokazuje djelotvornost takve isporuke inzulina. Treba napomenuti i da analiza \u017eelu\u010dane sluznice i nakon vi\u0161ekratnih takvih tretmana nije pokazala znakove o\u0161te\u0107enja \u017eeluca.<\/p>\n\n\n\n

Zasad je najve\u0107a boljka takvom isporu\u010divanju lijeka sama hrana. Iako se problem mo\u017ee izbje\u0107i uzimanjem mikrokapsule na prazan \u017eeludac, nau\u010dni tim je ve\u0107 zapo\u010deo rad na redizajniranju oblika. Tako bi kapsula djelovala i kad se u \u017eelucu nalazi hrana.<\/p>\n\n\n\n

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Postoje lijekovi koje nije mogu\u0107e popiti, jer ako ih se ne uzima putem injekcije, nego kroz usta \u2013 oni naprosto ne mogu djelovati. \u0160kolski primjer takvog lijeka je inzulin. To je zato \u0161to je on po sastavu biomakromolekula, protein. Kad…<\/p>\n

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